Menopause Is a Determinant of Breast Aromatase Expression and Its Associations With BMI, Inflammation, and Systemic Markers

CONTEXT: Most estrogen-dependent breast cancers occur after menopause, despite low levels of circulating estrogens. Breast expression of the estrogen-biosynthetic enzyme, aromatase, is proposed to drive breast cancer development after menopause. However, the effects of menopause on breast aromatase...

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Pubblicato in:J Clin Endocrinol Metab
Autori principali: Brown, Kristy A., Iyengar, Neil M., Zhou, Xi Kathy, Gucalp, Ayca, Subbaramaiah, Kotha, Wang, Hanhan, Giri, Dilip D., Morrow, Monica, Falcone, Domenick J., Wendel, Nils K., Winston, Lisle A., Pollak, Michael, Dierickx, Anneloor, Hudis, Clifford A., Dannenberg, Andrew J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2017
Soggetti:
Clinical Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5443335/
https://ncbi.nlm.nih.gov/pubmed/28323914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2016-3606
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