Leptin regulation of the p53-HIF1α/PKM2-aromatase axis in breast adipose stromal cells – a novel mechanism for the obesity-breast cancer link

BACKGROUND/OBJECTIVES: Obesity (body mass index (BMI) ≥ 30) is associated with an increased risk of estrogen-dependent breast cancer after menopause. Levels of aromatase, the rate-limiting enzyme in estrogen biosynthesis, are elevated in breast tissue of obese women. Recently, the regulation of arom...

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Detalhes bibliográficos
Publicado no:Int J Obes (Lond)
Main Authors: Zahid, Heba, Subbaramaiah, Kotha, Iyengar, Neil M., Zhou, Xi Kathy, Chen, I-Chun, Bhardwaj, Priya, Gucalp, Ayca, Morrow, Monica, Hudis, Clifford A., Dannenberg, Andrew J., Brown, Kristy A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936686/
https://ncbi.nlm.nih.gov/pubmed/29104286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ijo.2017.273
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