Leptin regulation of the p53-HIF1α/PKM2-aromatase axis in breast adipose stromal cells – a novel mechanism for the obesity-breast cancer link

BACKGROUND/OBJECTIVES: Obesity (body mass index (BMI) ≥ 30) is associated with an increased risk of estrogen-dependent breast cancer after menopause. Levels of aromatase, the rate-limiting enzyme in estrogen biosynthesis, are elevated in breast tissue of obese women. Recently, the regulation of arom...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Int J Obes (Lond)
Autors principals: Zahid, Heba, Subbaramaiah, Kotha, Iyengar, Neil M., Zhou, Xi Kathy, Chen, I-Chun, Bhardwaj, Priya, Gucalp, Ayca, Morrow, Monica, Hudis, Clifford A., Dannenberg, Andrew J., Brown, Kristy A.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936686/
https://ncbi.nlm.nih.gov/pubmed/29104286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ijo.2017.273
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars