Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis

Hyperactivation of EGFR/PI3K/AKT is a prominent feature of various human cancers. Thus, understanding how this molecular cascade is balanced is of great importance. We report here that the ubiquitin-specific protease USP43 is physically associated with the chromatin remodeling NuRD complex and catal...

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Published in:Cell Res
Main Authors: He, Lin, Liu, Xinhua, Yang, Jianguo, Li, Wanjin, Liu, Shumeng, Liu, Xujun, Yang, Ziran, Ren, Jie, Wang, Yue, Shan, Lin, Guan, Chengjian, Pei, Fei, Lei, Liandi, Zhang, Yu, Yi, Xia, Yang, Xiaohan, Liang, Jing, Liu, Rong, Sun, Luyang, Shang, Yongfeng
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123467/
https://ncbi.nlm.nih.gov/pubmed/30135474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-018-0079-6
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