JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component

BACKGROUND: Melanoma, originated from melanocytes located on the basal membrane of the epithelial tissue, is the most aggressive form of skin cancer that accounts for 75% of skin cancer-related death. Although it is believed that BRAF mutation and the mitogen-activated protein kinase (MAPK) pathway...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Liu, Xujun, Si, Wenzhe, Liu, Xinhua, He, Lin, Ren, Jie, Yang, Ziran, Yang, Jianguo, Li, Wanjin, Liu, Shumeng, Pei, Fei, Yang, Xiaohan, Sun, Luyang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5708181/
https://ncbi.nlm.nih.gov/pubmed/29187213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-017-0744-2
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