PAK Signaling Drives Acquired Drug Resistance to MAPK Inhibitors in BRAF-mutant Melanomas

Targeted BRAF inhibition (BRAFi) and combined BRAF and MEK inhibition (BRAFi+MEKi) therapies have significantly improved clinical outcomes in patients with metastatic melanoma. Unfortunately, the efficacy is beset by the acquisition of drug resistance(1–6). Here we investigated molecular mechanisms...

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Publicado no:Nature
Main Authors: Lu, Hezhe, Liu, Shujing, Zhang, Gao, Wu, Bin, Zhu, Yueyao, Frederick, Dennie T., Hu, Yi, Zhong, Wenqun, Randell, Sergio, Sadek, Norah, Zhang, Wei, Chen, Gang, Cheng, Chaoran, Zeng, Jingwen, Wu, Lawrence W., Zhang, Jie, Liu, Xiaoming, Xu, Wei, Krepler, Clemens, Sproesser, Katrin, Xiao, Min, Miao, Benchun, Liu, Jianglan, Song, Claire D., Liu, Jephrey Y., Karakousis, Giorgos C., Schuchter, Lynn M., Lu, Yiling, Mills, Gordon, Cong, Yusheng, Chernoff, Jonathan, Guo, Jun, Boland, Genevieve M., Sullivan, Ryan J., Wei, Zhi, Field, Jeffrey, Amaravadi, Ravi K., Flaherty, Keith T., Herlyn, Meenhard, Xu, Xiaowei, Guo, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5891348/
https://ncbi.nlm.nih.gov/pubmed/28953887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24040
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