Enhancing CD8(+) T cell fatty acid catabolism within a metabolically challenging tumor microenvironment increases the efficacy of melanoma immunotherapy

How tumor-infiltrating T lymphocytes (TILs) adapt to the metabolic constrains within the tumor microenvironment (TME) and to what degree this affects their ability to combat tumor progression remain poorly understood. Using mouse melanoma models, we report that CD8(+) TILs enhance PPAR-α signaling a...

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I publikationen:Cancer Cell
Huvudupphovsmän: Zhang, Ying, Kurupati, Raj, Liu, Ling, Zhou, Xiang Yang, Zhang, Gao, Hudaihed, Abeer, Filisio, Flavia, Giles-Davis, Wynetta, Xu, Xiaowei, Karakousis, Giorgos C., Schuchter, Lynn M., Xu, Wei, Amaravadi, Ravi, Xiao, Min, Sadek, Norah, Krepler, Clemens, Herlyn, Meenhard, Freeman, Gordon J, Rabinowitz, Joshua D, Ertl, Hildegund CJ
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5751418/
https://ncbi.nlm.nih.gov/pubmed/28898698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.08.004
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