Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis

The histone demethylase PHF8 has been implicated in multiple pathological disorders, including X-linked mental retardation and tumorigenesis. However, it is not clear how the abundance and function of PHF8 are regulated. Here, we report that PHF8 physically associates with the deubiquitinase USP7. S...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Clin Invest
Päätekijät: Wang, Qian, Ma, Shuai, Song, Nan, Li, Xin, Liu, Ling, Yang, Shangda, Ding, Xiang, Shan, Lin, Zhou, Xing, Su, Dongxue, Wang, Yue, Zhang, Qi, Liu, Xinhua, Yu, Na, Zhang, Kai, Shang, Yongfeng, Yao, Zhi, Shi, Lei
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2016
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887182/
https://ncbi.nlm.nih.gov/pubmed/27183383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85747
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