Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis

The histone demethylase PHF8 has been implicated in multiple pathological disorders, including X-linked mental retardation and tumorigenesis. However, it is not clear how the abundance and function of PHF8 are regulated. Here, we report that PHF8 physically associates with the deubiquitinase USP7. S...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Wang, Qian, Ma, Shuai, Song, Nan, Li, Xin, Liu, Ling, Yang, Shangda, Ding, Xiang, Shan, Lin, Zhou, Xing, Su, Dongxue, Wang, Yue, Zhang, Qi, Liu, Xinhua, Yu, Na, Zhang, Kai, Shang, Yongfeng, Yao, Zhi, Shi, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887182/
https://ncbi.nlm.nih.gov/pubmed/27183383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85747
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