Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis

T-cells are crucial in maintanence of intestinal homeostasis, however, it is still unclear how microbiota metabolites regulate T-effector cells. Here we show gut microbiota-derived short-chain fatty acids (SCFAs) promote microbiota antigen-specific Th1 cell IL-10 production, mediated by G-protein co...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Sun, Mingming, Wu, Wei, Chen, Liang, Yang, Wenjing, Huang, Xiangsheng, Ma, Caiyun, Chen, Feidi, Xiao, Yi, Zhao, Ye, Ma, Chunyan, Yao, Suxia, Carpio, Victor H., Dann, Sara M., Zhao, Qihong, Liu, Zhanju, Cong, Yingzi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120873/
https://ncbi.nlm.nih.gov/pubmed/30177845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05901-2
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