Microbiota metabolite short-chain fatty acids facilitate mucosal adjuvant activity of cholera toxin through GPR43

The gut microbiota has been shown critical for mucosal adjuvant activity of cholera toxin (CT), a potent mucosal adjuvant. However, the mechanisms involved remain largely unknown. Here, we report that depletion of gut bacteria significantly decreased mucosal and systemic antibody responses in mice o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Immunol
Prif Awduron: Yang, Wenjing, Xiao, Yi, Huang, Xiangsheng, Chen, Feidi, Sun, Mingming, Bilotta, Anthony J, Xu, Leiqi, Lu, Yao, Yao, Suxia, Zhao, Qihong, Liu, Zhanju, Cong, Yingzi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581581/
https://ncbi.nlm.nih.gov/pubmed/31076530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801068
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