GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3

The antimicrobial peptides (AMP) produced by intestinal epithelial cells (IEC) play crucial roles in the regulation of intestinal homeostasis by controlling microbiota. Gut microbiota has been shown to promote IEC expression of RegIIIγ and certain defensins. However, the mechanisms involved are stil...

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Detalhes bibliográficos
Publicado no:Mucosal Immunol
Main Authors: Zhao, Ye, Chen, Feidi, Wu, Wei, Sun, Mingming, Bilotta, Anthony J., Yao, Suxia, Xiao, Yi, Huang, Xiangsheng, Eaves-Pyles, Tonyia D., Golovko, George, Fofanov, Yuriy, D’Souza, Warren, Zhao, Qihong, Liu, Zhanju, Cong, Yingzi
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976519/
https://ncbi.nlm.nih.gov/pubmed/29411774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2017.118
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