GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3

The antimicrobial peptides (AMP) produced by intestinal epithelial cells (IEC) play crucial roles in the regulation of intestinal homeostasis by controlling microbiota. Gut microbiota has been shown to promote IEC expression of RegIIIγ and certain defensins. However, the mechanisms involved are stil...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mucosal Immunol
Egile Nagusiak: Zhao, Ye, Chen, Feidi, Wu, Wei, Sun, Mingming, Bilotta, Anthony J., Yao, Suxia, Xiao, Yi, Huang, Xiangsheng, Eaves-Pyles, Tonyia D., Golovko, George, Fofanov, Yuriy, D’Souza, Warren, Zhao, Qihong, Liu, Zhanju, Cong, Yingzi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976519/
https://ncbi.nlm.nih.gov/pubmed/29411774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2017.118
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