RORγt represses Th17 cell IL-10 production to maintain their pathogenicity in inducing intestinal inflammation

The role of retinoid-related orphan receptor gamma t (RORγt) in Th17 cell differentiation has been well-established, however, how it regulates other T cell lineages is still not clearly understood. We report here that in mice while promoting Th17 cell differentiation, RORγt inhibited IL-10 productio...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Sun, Mingming, He, Chong, Chen, Liang, Yang, Wenjing, Wu, Wei, Chen, Feidi, Cao, Anthony T., Yao, Suxia, Dann, Sara M, Dhar, T. G. Murali, Salter-Cid, Luisa, Zhao, Qihong, Liu, Zhanju, Cong, Yingzi
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310078/
https://ncbi.nlm.nih.gov/pubmed/30478092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701697
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