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Noncanonical secondary structures arising from non-B DNA motifs are determinants of mutagenesis

Somatic mutations show variation in density across cancer genomes. Previous studies have shown that chromatin organization and replication time domains are correlated with, and thus predictive of, this variation. Here, we analyze 1809 whole-genome sequences from 10 cancer types to show that a subset...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Genome Res
Päätekijät: Georgakopoulos-Soares, Ilias, Morganella, Sandro, Jain, Naman, Hemberg, Martin, Nik-Zainal, Serena
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cold Spring Harbor Laboratory Press 2018
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120622/
https://ncbi.nlm.nih.gov/pubmed/30104284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.231688.117
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