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Divergent synthesis of Thapsigargin analogs
Thapsigargin (3) is a potent inhibitor of the SERCA-pump protein, with potential for application in a variety of medicinal areas. The efficient and scalable syntheses of thapsigargin (3) and nortrilobolide (2) have been disclosed previously. To demonstrate the modularity of the previous routes, thre...
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| Izdano u: | Bioorg Med Chem Lett |
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| Glavni autori: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6119632/ https://ncbi.nlm.nih.gov/pubmed/29636219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.03.065 |
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