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Nineteen-Step Total Synthesis of (+)-Phorbol

Phorbol, the flagship member of the tigliane diterpene family, has been known for over 80 years and has attracted attention from scores of chemists and biologists due to its intriguing chemical structure and the medicinal potential of phorbol esters.(1) Access to useful quantities of phorbol and rel...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Kawamura, Shuhei, Chu, Hang, Felding, Jakob, Baran, Phil S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833603/
https://ncbi.nlm.nih.gov/pubmed/27007853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17153
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