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Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactive
Congenital neutropenia is characterized by low absolute neutrophil numbers in blood, leading to recurrent bacterial infections, and patients often require life-long granulocyte CSF (G-CSF) support. X-linked neutropenia (XLN) is caused by gain-of-function mutations in the actin regulator Wiskott-Aldr...
Guardat en:
| Publicat a: | J Clin Invest |
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| Autors principals: | , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6118594/ https://ncbi.nlm.nih.gov/pubmed/30124469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64772 |
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