Constitutive activation of WASp leads to abnormal cytotoxic cells with increased granzyme B and degranulation response to target cells

X-linked neutropenia (XLN) is caused by gain-of-function mutations in the actin regulator Wiskott-Aldrich Syndrome protein (WASp). XLN patients have reduced numbers of cytotoxic cells in peripheral blood; however, their capacity to kill tumor cells remains to be determined. Here, we examined NK and...

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Bibliografski detalji
Izdano u:JCI Insight
Glavni autori: Kritikou, Joanna S., Oliveira, Mariana M.S., Record, Julien, Saeed, Mezida B., Nigam, Saket M., He, Minghui, Keszei, Marton, Wagner, Arnika K., Brauner, Hanna, Sendel, Anton, Sedimbi, Saikiran K., Rentouli, Stamatina, Lane, David P., Snapper, Scott B., Kärre, Klas, Vandenberghe, Peter, Orange, Jordan S., Westerberg, Lisa S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2021
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026198/
https://ncbi.nlm.nih.gov/pubmed/33621210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.140273
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