Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies

Humoral immunodeficiency caused by mutations in the Wiskott-Aldrich syndrome protein (WASp) is associated with failure to respond to common pathogens and high frequency of autoimmunity. Here we addressed the question how deficiency in WASp and the homologous protein N-WASp skews the immune response...

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Veröffentlicht in:J Autoimmun
Hauptverfasser: Dahlberg, Carin I.M., Torres, Magda-Liz, Petersen, Sven H., Baptista, Marisa A.P., Keszei, Marton, Volpi, Stefano, Grasset, Emilie K., Karlsson, Mikael C.I., Walter, Jolan E., Snapper, Scott B., Notarangelo, Luigi D., Westerberg, Lisa S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245946/
https://ncbi.nlm.nih.gov/pubmed/26143192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2015.06.003
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