N-WASP is required for B-cell–mediated autoimmunity in Wiskott-Aldrich syndrome

Mutations of the Wiskott-Aldrich syndrome gene (WAS) are responsible for Wiskott-Aldrich syndrome (WAS), a disease characterized by thrombocytopenia, eczema, immunodeficiency, and autoimmunity. Mice with conditional deficiency of Was in B lymphocytes (B/WcKO) have revealed a critical role for WAS pr...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Volpi, Stefano, Santori, Elettra, Abernethy, Katrina, Mizui, Masayuki, Dahlberg, Carin I. M., Recher, Mike, Capuder, Kelly, Csizmadia, Eva, Ryan, Douglas, Mathew, Divij, Tsokos, George C., Snapper, Scott, Westerberg, Lisa S., Thrasher, Adrian J., Candotti, Fabio, Notarangelo, Luigi D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713162/
https://ncbi.nlm.nih.gov/pubmed/26468226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-05-643817
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