FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse

The FKBP-12-rapamycin associated protein (FRAP, also known as mTOR and RAFT-1) is a member of the phosphoinositide kinase related kinase family. FRAP has serine/threonine kinase activity and mediates the cellular response to mitogens through signaling to p70s6 kinase (p70(s6k)) and 4E-BP1, resulting...

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Bibliographic Details
Main Authors: Hentges, Kathryn E., Sirry, Baheya, Gingeras, Anne-Claude, Sarbassov, Dos, Sonenberg, Nahum, Sabatini, David, Peterson, Andrew S.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC61121/
https://ncbi.nlm.nih.gov/pubmed/11707573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.241184198
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