Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR

Recent evidence places the FRAP/mTOR kinase downstream of the phosphatidyl inositol 3-kinase/Akt-signaling pathway, which is up-regulated in multiple cancers because of loss of the PTEN tumor suppressor gene. We performed biological and biochemical studies to determine whether PTEN-deficient cancer...

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Autors principals: Neshat, Mehran S., Mellinghoff, Ingo K., Tran, Chris, Stiles, Bangyan, Thomas, George, Petersen, Roseann, Frost, Philip, Gibbons, James J., Wu, Hong, Sawyers, Charles L.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC56958/
https://ncbi.nlm.nih.gov/pubmed/11504908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171076798
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