Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR

Recent evidence places the FRAP/mTOR kinase downstream of the phosphatidyl inositol 3-kinase/Akt-signaling pathway, which is up-regulated in multiple cancers because of loss of the PTEN tumor suppressor gene. We performed biological and biochemical studies to determine whether PTEN-deficient cancer...

Popoln opis

Bibliografske podrobnosti

izdano v:	Proc Natl Acad Sci U S A
Principais autores:	Neshat, Mehran S., Mellinghoff, Ingo K., Tran, Chris, Stiles, Bangyan, Thomas, George, Petersen, Roseann, Frost, Philip, Gibbons, James J., Wu, Hong, Sawyers, Charles L.
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 2001
Teme:	Biological Sciences
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC56958/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11504908/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.171076798
Oznake:	Označite Brez oznak, prvi označite!