Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
Recent evidence places the FRAP/mTOR kinase downstream of the phosphatidyl inositol 3-kinase/Akt-signaling pathway, which is up-regulated in multiple cancers because of loss of the PTEN tumor suppressor gene. We performed biological and biochemical studies to determine whether PTEN-deficient cancer...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2001
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC56958/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11504908/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.171076798 |
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