Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice

BACKGROUND: Germline mutations in the tumor suppressor PTEN predispose human beings to breast cancer, and genetic and epigenetic alterations of PTEN are also detected in sporadic human breast cancer. Germline Pten mutations in mice lead to the development of a variety of tumors, but mammary carcinom...

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Hauptverfasser: Li, Yi, Podsypanina, Katrina, Liu, Xiufan, Crane, Allison, Tan, Lee K, Parsons, Ramon, Varmus, Harold E
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2001
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC29091/
https://ncbi.nlm.nih.gov/pubmed/11178110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-2-2
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