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Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression
The PTEN gene encodes a lipid phosphatase that negatively regulates the phosphatidylinositol 3-kinase pathway and is inactivated in a wide variety of malignant neoplasms. High rates of loss of heterozygosity are observed at the 10q23.3 region containing the human PTEN gene in prostate cancer and oth...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The National Academy of Sciences
2001
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC58769/ https://ncbi.nlm.nih.gov/pubmed/11553783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.201167798 |
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