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In renal cell carcinoma the PTEN splice variant PTEN-Δ shows similar function as the tumor suppressor PTEN itself

Abstract Background Loss of PTEN is involved in tumor progression of several tumor entities including renal cell carcinoma (RCC). During the translation process PTEN generates a number of splice variants, including PTEN-Δ. We analyzed the impact of PTEN-Δ in RCC progression. Methods In specimens of...

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Autori principali: Ines Breuksch, Jonas Welter, Heide-Katharina Bauer, Thorsten Enklaar, Sebastian Frees, Joachim W. Thüroff, Annette Hasenburg, Dirk Prawitt, Walburgis Brenner
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2018-06-01
Serie:Cell Communication and Signaling
Soggetti:
PTEN
Renal cell carcinoma
Splice variant
PTEN-Δ
Tumor progression
Metastasis
Accesso online:http://link.springer.com/article/10.1186/s12964-018-0247-9
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