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Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression

The PTEN gene encodes a lipid phosphatase that negatively regulates the phosphatidylinositol 3-kinase pathway and is inactivated in a wide variety of malignant neoplasms. High rates of loss of heterozygosity are observed at the 10q23.3 region containing the human PTEN gene in prostate cancer and oth...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Kwabi-Addo, Bernard, Giri, Dipak, Schmidt, Karen, Podsypanina, Katrina, Parsons, Ramon, Greenberg, Norman, Ittmann, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2001
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC58769/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11553783/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.201167798
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