Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression

The PTEN gene encodes a lipid phosphatase that negatively regulates the phosphatidylinositol 3-kinase pathway and is inactivated in a wide variety of malignant neoplasms. High rates of loss of heterozygosity are observed at the 10q23.3 region containing the human PTEN gene in prostate cancer and oth...

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Bibliografiska uppgifter
Huvudupphovsmän: Kwabi-Addo, Bernard, Giri, Dipak, Schmidt, Karen, Podsypanina, Katrina, Parsons, Ramon, Greenberg, Norman, Ittmann, Michael
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 2001
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC58769/
https://ncbi.nlm.nih.gov/pubmed/11553783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.201167798
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