Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression
The PTEN gene encodes a lipid phosphatase that negatively regulates the phosphatidylinositol 3-kinase pathway and is inactivated in a wide variety of malignant neoplasms. High rates of loss of heterozygosity are observed at the 10q23.3 region containing the human PTEN gene in prostate cancer and oth...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2001
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC58769/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11553783/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.201167798 |
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