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Signaling from Akt to FRAP/TOR Targets both 4E-BP and S6K in Drosophila melanogaster
The eIF4E-binding proteins (4E-BPs) interact with translation initiation factor 4E to inhibit translation. Their binding to eIF4E is reversed by phosphorylation of several key Ser/Thr residues. In Drosophila, S6 kinase (dS6K) and a single 4E-BP (d4E-BP) are phosphorylated via the insulin and target...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2003
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC309682/ https://ncbi.nlm.nih.gov/pubmed/14645523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.24.9117-9126.2003 |
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