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Signaling from Akt to FRAP/TOR Targets both 4E-BP and S6K in Drosophila melanogaster

The eIF4E-binding proteins (4E-BPs) interact with translation initiation factor 4E to inhibit translation. Their binding to eIF4E is reversed by phosphorylation of several key Ser/Thr residues. In Drosophila, S6 kinase (dS6K) and a single 4E-BP (d4E-BP) are phosphorylated via the insulin and target...

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Udgivet i:Mol Cell Biol
Principais autores: Miron, Mathieu, Lasko, Paul, Sonenberg, Nahum
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2003
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309682/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14645523/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.24.9117-9126.2003
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