Signaling from Akt to FRAP/TOR Targets both 4E-BP and S6K in Drosophila melanogaster

The eIF4E-binding proteins (4E-BPs) interact with translation initiation factor 4E to inhibit translation. Their binding to eIF4E is reversed by phosphorylation of several key Ser/Thr residues. In Drosophila, S6 kinase (dS6K) and a single 4E-BP (d4E-BP) are phosphorylated via the insulin and target...

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Vydáno v:	Mol Cell Biol
Hlavní autoři:	Miron, Mathieu, Lasko, Paul, Sonenberg, Nahum
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis 2003
Témata:	Cell Growth and Development
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309682/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14645523/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.24.9117-9126.2003
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