LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation

Propagation of α-synuclein aggregates has been suggested as a contributing factor in Parkinson’s disease (PD) progression. However, the molecular mechanisms underlying α-synuclein aggregation are not fully understood. Here, we demonstrate in cell culture, nematode, and rodent models of PD that leuci...

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Udgivet i:Nat Commun
Main Authors: Bae, Eun-Jin, Kim, Dong-Kyu, Kim, Changyoun, Mante, Michael, Adame, Anthony, Rockenstein, Edward, Ulusoy, Ayse, Klinkenberg, Michael, Jeong, Ga Ram, Bae, Jae Ryul, Lee, Cheolsoon, Lee, He-Jin, Lee, Byung-Dae, Di Monte, Donato A., Masliah, Eliezer, Lee, Seung-Jae
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110743/
https://ncbi.nlm.nih.gov/pubmed/30150626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05958-z
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