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Activation of the G(i) protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia
Primary cilia are solitary organelles that emanate from the plasma membrane during growth arrest in almost all mammalian cells. The canonical Hedgehog (HH) pathway requires trafficking of the G protein-coupled receptor SMOOTHENED (SMO) and the GLI transcription factors to the primary cilium upon bin...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6110505/ https://ncbi.nlm.nih.gov/pubmed/30148884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203170 |
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