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Activation of the G(i) protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia
Primary cilia are solitary organelles that emanate from the plasma membrane during growth arrest in almost all mammalian cells. The canonical Hedgehog (HH) pathway requires trafficking of the G protein-coupled receptor SMOOTHENED (SMO) and the GLI transcription factors to the primary cilium upon bin...
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| Gepubliceerd in: | PLoS One |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6110505/ https://ncbi.nlm.nih.gov/pubmed/30148884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203170 |
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