Fatostatin induces pro- and anti-apoptotic lipid accumulation in breast cancer

Given the dependence of cancers on de novo lipogenesis, we tested the effect of fatostatin, a small molecule thought to target this pathway by blocking activation of SREBP transcription factors, in breast cancer cell lines and xenograft tumors. We found that estrogen receptor (ER) positive cells wer...

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Publicat a:Oncogenesis
Autors principals: Brovkovych, Viktor, Izhar, Yasir, Danes, Jeanne M., Dubrovskyi, Oleskii, Sakallioglu, Isin T., Morrow, Lauren M., Atilla-Gokcumen, G. Ekin, Frasor, Jonna
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6107643/
https://ncbi.nlm.nih.gov/pubmed/30140005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-018-0076-0
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