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Fatostatin induces pro- and anti-apoptotic lipid accumulation in breast cancer
Given the dependence of cancers on de novo lipogenesis, we tested the effect of fatostatin, a small molecule thought to target this pathway by blocking activation of SREBP transcription factors, in breast cancer cell lines and xenograft tumors. We found that estrogen receptor (ER) positive cells wer...
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| Publicado no: | Oncogenesis |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6107643/ https://ncbi.nlm.nih.gov/pubmed/30140005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-018-0076-0 |
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