The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens

A C1858T single nucleotide polymorphism within PTPN22 (which encodes PTPN22(R620W)) is associated with an enhanced susceptibility to multiple autoimmune diseases including type 1 diabetes and rheumatoid arthritis. Many of the associated autoimmune diseases have an autoantibody component to their pat...

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Publicado no:Sci Rep
Main Authors: Clarke, Fiona, Purvis, Harriet A., Sanchez-Blanco, Cristina, Gutiérrez-Martinez, Enrique, Cornish, Georgina H., Zamoyska, Rose, Guermonprez, Pierre, Cope, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6107551/
https://ncbi.nlm.nih.gov/pubmed/30139951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31179-x
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