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Synthesis of an organoinsulin molecule that can be activated by antibody catalysis
We have developed a methodology of prodrug delivery by using a modified insulin species whose biological activity potentially can be regulated in vivo. Native insulin was derivatized with aldol-terminated chemical modifications that can be selectively removed by the catalytic aldolase antibody 38C2...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The National Academy of Sciences
2001
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC61072/ https://ncbi.nlm.nih.gov/pubmed/11707596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.241516698 |
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