Synthesis of an organoinsulin molecule that can be activated by antibody catalysis

We have developed a methodology of prodrug delivery by using a modified insulin species whose biological activity potentially can be regulated in vivo. Native insulin was derivatized with aldol-terminated chemical modifications that can be selectively removed by the catalytic aldolase antibody 38C2...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Worrall, Dorothy S., McDunn, Jonathan E., List, Benjamin, Reichart, Donna, Hevener, Andrea, Gustafson, Thomas, Barbas, Carlos F., Lerner, Richard A., Olefsky, Jerrold M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC61072/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11707596/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.241516698
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