Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task
Catalytic aldolase antibodies generated by immunization with two different, but structurally related, β-diketone haptens were cloned and sequenced to study similarities and differences between independently evolved catalysts. Kinetic and sequence analysis coupled with mutagenesis, structural, and mo...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2000
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18110/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10760259/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.8.3878 |
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