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In vivo activity in a catalytic antibody-prodrug system: Antibody catalyzed etoposide prodrug activation for selective chemotherapy

Effective chemotherapy remains a key issue for successful cancer treatment in general and neuroblastoma in particular. Here we report a chemotherapeutic strategy based on catalytic antibody-mediated prodrug activation. To study this approach in an animal model of neuroblastoma, we have synthesized p...

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Bibliografski detalji
Glavni autori: Shabat, Doron, Lode, Holger N., Pertl, Ursula, Reisfeld, Ralph A., Rader, Christoph, Lerner, Richard A., Barbas, Carlos F.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2001
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC34702/
https://ncbi.nlm.nih.gov/pubmed/11404472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.131187998
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