In vivo activity in a catalytic antibody-prodrug system: Antibody catalyzed etoposide prodrug activation for selective chemotherapy

Effective chemotherapy remains a key issue for successful cancer treatment in general and neuroblastoma in particular. Here we report a chemotherapeutic strategy based on catalytic antibody-mediated prodrug activation. To study this approach in an animal model of neuroblastoma, we have synthesized p...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Shabat, Doron, Lode, Holger N., Pertl, Ursula, Reisfeld, Ralph A., Rader, Christoph, Lerner, Richard A., Barbas, Carlos F.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34702/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11404472/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.131187998
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