Evidence for Compartmentalized Axonal Mitochondrial Biogenesis: Mitochondrial DNA Replication Increases in Distal Axons As an Early Response to Parkinson's Disease-Relevant Stress

Dysregulation of mitochondrial biogenesis is implicated in the pathogenesis of neurodegenerative diseases such as Parkinson's disease (PD). However, it is not clear how mitochondrial biogenesis is regulated in neurons, with their unique compartmentalized anatomy and energetic demands. This is p...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Van Laar, Victor S., Arnold, Beth, Howlett, Evan H., Calderon, Michael J., St. Croix, Claudette M., Greenamyre, J. Timothy, Sanders, Laurie H., Berman, Sarah B.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104298/
https://ncbi.nlm.nih.gov/pubmed/30030401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0541-18.2018
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