TSG101 negatively regulates mitochondrial biogenesis in axons

There is a tight association between mitochondrial dysfunction and neurodegenerative diseases and axons that are particularly vulnerable to degeneration, but how mitochondria are maintained in axons to support their physiology remains poorly defined. In an in vivo forward genetic screen for mutants...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Lin, Tzu-Huai, Bis-Brewer, Dana M., Sheehan, Amy E., Townsend, Louise N., Maddison, Daniel C., Züchner, Stephan, Smith, Gaynor A., Freeman, Marc R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2021
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8157921/
https://ncbi.nlm.nih.gov/pubmed/33972422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2018770118
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