Evidence for Compartmentalized Axonal Mitochondrial Biogenesis: Mitochondrial DNA Replication Increases in Distal Axons As an Early Response to Parkinson's Disease-Relevant Stress

Dysregulation of mitochondrial biogenesis is implicated in the pathogenesis of neurodegenerative diseases such as Parkinson's disease (PD). However, it is not clear how mitochondrial biogenesis is regulated in neurons, with their unique compartmentalized anatomy and energetic demands. This is p...

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Detaylı Bibliyografya
Yayımlandı:J Neurosci
Asıl Yazarlar: Van Laar, Victor S., Arnold, Beth, Howlett, Evan H., Calderon, Michael J., St. Croix, Claudette M., Greenamyre, J. Timothy, Sanders, Laurie H., Berman, Sarah B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Society for Neuroscience 2018
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104298/
https://ncbi.nlm.nih.gov/pubmed/30030401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0541-18.2018
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