Structures of ubiquitin-like (Ubl) and Hsp90-like domains of sacsin provide insight into pathological mutations

Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a neurodegenerative disease that is caused by mutations in the SACS gene. The product of this gene is a very large 520-kDa cytoplasmic protein, sacsin, with a ubiquitin-like (Ubl) domain at the N terminus followed by three large s...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Ménade, Marie, Kozlov, Guennadi, Trempe, Jean-François, Pande, Harshit, Shenker, Solomon, Wickremasinghe, Sihara, Li, Xinlu, Hojjat, Hamed, Dicaire, Marie-Josée, Brais, Bernard, McPherson, Peter S., Wong, Michael J. H., Young, Jason C., Gehring, Kalle
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102131/
https://ncbi.nlm.nih.gov/pubmed/29945973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003939
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