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A Ubl/ubiquitin switch in the activation of Parkin
Mutations in Parkin and PINK1 cause an inherited early-onset form of Parkinson's disease. The two proteins function together in a mitochondrial quality control pathway whereby PINK1 accumulates on damaged mitochondria and activates Parkin to induce mitophagy. How PINK1 kinase activity releases...
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| Publicado no: | EMBO J |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4609182/ https://ncbi.nlm.nih.gov/pubmed/26254305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201592237 |
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