A Ubl/ubiquitin switch in the activation of Parkin

Mutations in Parkin and PINK1 cause an inherited early-onset form of Parkinson's disease. The two proteins function together in a mitochondrial quality control pathway whereby PINK1 accumulates on damaged mitochondria and activates Parkin to induce mitophagy. How PINK1 kinase activity releases...

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Dades bibliogràfiques
Publicat a:EMBO J
Autors principals: Sauvé, Véronique, Lilov, Asparouh, Seirafi, Marjan, Vranas, Marta, Rasool, Shafqat, Kozlov, Guennadi, Sprules, Tara, Wang, Jimin, Trempe, Jean-François, Gehring, Kalle
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Ltd 2015
Matèries:
Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609182/
https://ncbi.nlm.nih.gov/pubmed/26254305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201592237
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